WebProteini. Full gene name according to HGNC. TLE family member 3, transcriptional corepressor. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. TLE3 (ESG, ESG3, GRG3, HsT18976, KIAA1547) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). WebExpression of TLE3 (ESG, ESG3, GRG3, HsT18976, KIAA1547) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
Frequency of TLE3 overexpression in breast carcinoma subtypes …
WebThe TLE3 is a member of the family of the transducin-like enhancer of split, and is a transcriptional repressor homolog of the protein Groucho, which is a part of the Notch signaling cascade in Drosophila melanogaster 16 that appears to be expressed periodically during the M phase of the cell cycle. 17 The Notch signaling pathway controls the … WebIn conclusion, the present study demonstrated that miR-3677 promoted BC cell proliferation, migration and invasion by inhibiting TLE3 expression, which provided a novel mechanism and a promising therapeutic target for patients with BC. Keywords: breast cancer; cell metastasis; cell proliferation; microRNA-3677; transducin-like enhancer of Split3. sharper image heated mug usb
Frontiers Roles of transducin-like enhancer of split (TLE) family ...
WebApr 4, 2024 · Here we report that the transcriptional corepressor TLE3 is a guardian of luminal cell fate in breast cancer and operates independently of the estrogen receptor. In luminal breast cancer, TLE3 actively repressed the gene-expression signature associated with highly aggressive basal-like breast cancers (BLBC). WebMar 23, 2009 · TLE3 is a member of the transducin-like enhancer of split (TLE) family of proteins that have been implicated in the tumorgenesis and classification of sarcomas [ 9, 10 ]. It is a transcriptional repressor homologous to drosophila groucho proteins involved in repressing epithelial cell fate determination [ 11, 12 ]. WebExpression of TLE3 in cancer - Summary - The Human Protein Atlas TLE3 PATHOLOGY CANCER ANTIBODIES AND VALIDATION Dictionary Human pathology PROGNOSTIC SUMMARYi Prognostic marker in cervical cancer (favorable) Cervical cancer p<0.001 RNA EXPRESSION OVERVIEWi TCGA dataseti RNA cancer category: Low cancer specificity sharper image headphones sbt559