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Tle3 in cancer

WebProteini. Full gene name according to HGNC. TLE family member 3, transcriptional corepressor. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. TLE3 (ESG, ESG3, GRG3, HsT18976, KIAA1547) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). WebExpression of TLE3 (ESG, ESG3, GRG3, HsT18976, KIAA1547) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.

Frequency of TLE3 overexpression in breast carcinoma subtypes …

WebThe TLE3 is a member of the family of the transducin-like enhancer of split, and is a transcriptional repressor homolog of the protein Groucho, which is a part of the Notch signaling cascade in Drosophila melanogaster 16 that appears to be expressed periodically during the M phase of the cell cycle. 17 The Notch signaling pathway controls the … WebIn conclusion, the present study demonstrated that miR-3677 promoted BC cell proliferation, migration and invasion by inhibiting TLE3 expression, which provided a novel mechanism and a promising therapeutic target for patients with BC. Keywords: breast cancer; cell metastasis; cell proliferation; microRNA-3677; transducin-like enhancer of Split3. sharper image heated mug usb https://decemchair.com

Frontiers Roles of transducin-like enhancer of split (TLE) family ...

WebApr 4, 2024 · Here we report that the transcriptional corepressor TLE3 is a guardian of luminal cell fate in breast cancer and operates independently of the estrogen receptor. In luminal breast cancer, TLE3 actively repressed the gene-expression signature associated with highly aggressive basal-like breast cancers (BLBC). WebMar 23, 2009 · TLE3 is a member of the transducin-like enhancer of split (TLE) family of proteins that have been implicated in the tumorgenesis and classification of sarcomas [ 9, 10 ]. It is a transcriptional repressor homologous to drosophila groucho proteins involved in repressing epithelial cell fate determination [ 11, 12 ]. WebExpression of TLE3 in cancer - Summary - The Human Protein Atlas TLE3 PATHOLOGY CANCER ANTIBODIES AND VALIDATION Dictionary Human pathology PROGNOSTIC SUMMARYi Prognostic marker in cervical cancer (favorable) Cervical cancer p<0.001 RNA EXPRESSION OVERVIEWi TCGA dataseti RNA cancer category: Low cancer specificity sharper image headphones sbt559

Pan-Cancer Analysis of TLE3 Revealed Its Value in Tumor ... - PubMed

Category:Topoisomerase II alpha and TLE3 as predictive markers of response to …

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Tle3 in cancer

TLE3 as a Candidate Biomarker of Response to Taxane …

WebAug 18, 2015 · This association between TLE3 staining and outcome among women treated with taxanes was subsequently validated in independent cohorts of triple negative breast cancer patients (Kulkarni et al ... WebNov 22, 2024 · TLE3 was tested for independence in the Clearview Cancer Institute in Huntsville (CCIH) and Roswell Park Cancer Institute (RPCI) triple-negative cohorts with a range of standard clinical ...

Tle3 in cancer

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WebHere we assemble an aggregate cohort of 1,546 prostate cancers and show that FOXA1 alterations fall into three structural classes that diverge in clinical incidence and genetic co-alteration profiles, with a collective prevalence of 35%. Class-1 activating mutations originate in early prostate cancer without alterations in ETS or SPOP ... WebJan 25, 2024 · In luminal breast cancer, TLE3 actively repressed the gene expression signature associated with highly aggressive basal-like breast cancers (BLBC). Moreover, maintenance of the luminal lineage ...

WebDec 23, 2024 · TLE3 was selected as a potential target of miR-3677. The wild-type 3′-untranslated region (UTR) of TLE3 mRNA was subcloned into the pGL3 vector (Promega … WebTLE3 also regulates metabolism and cell fate in the bone [28,29,30], pancreas [31,32,33], muscle , embryonic stem cell [35,36], and cancer [17,27,37,38,39]. It is interesting to note …

Webhuman lung tissue were subjected to SDS PAGE followed by western blot with 11372-1-AP (TLE3 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. IP Result of anti-TLE3 (IP:11372-1-AP, 4ug; Detection:11372-1-AP 1:300) with HeLa cells lysate 1600ug. Immunohistochemical analysis of paraffin-embedded human breast cancer slide ... WebNov 1, 2024 · Recent studies have revealed that TLEs are dysregulated in certain human cancer types and may function as oncogenes or tumor suppressors in different contexts. ... TLE3 ubiquitination and ...

WebTLE3, β-tubulin class III, and GSTP1 were expressed in 24 cases (46.2%), 21 cases (40.4%) and 24 cases (46.2%), respectively, among the 52 patients investigated. The expression of …

WebDec 23, 2024 · TLE3 was selected as a potential target of miR-3677. The wild-type 3′-untranslated region (UTR) of TLE3 mRNA was subcloned into the pGL3 vector (Promega Corporation, Madison, WI, USA). The cells were co-transfected with 80 nmol/l miR-3677 or 80 nmol/l miR-3677-mut and 200 ng wild-type vectors in the presence of 1 ng pRL-TK Renilla … pork loin ribeye chopsWebNov 11, 2024 · In studies of ovarian and breast cancers, increased TLE3 expression was related to a higher response rate to taxane-based chemotherapy, but TLE3 expression … pork loin rib roast recipes for ovenWebCanine Cancer Care, Inc Oct 2015 - 2024 2 years. Animal Welfare Raising canine cancer awareness, providing financial assistance for treatment, and supporting research. ... pork loin rib chops recipes thick