Thiophene metabolism
WebApr 10, 2024 · Ketoisovalerate decarboxylase (KID) is the second decarboxylase isolated from L. lactis with almost 90% amino acid sequence identity with KdcA. 212 Therefore, KID also participates in the metabolism of amino acids, where it is involved in the production of 3-methylbutanal starting from leucine. 214 3-Methylbutanal is the aroma with caramel ... Thiophene is a heterocyclic compound with the formula C4H4S. Consisting of a planar five-membered ring, it is aromatic as indicated by its extensive substitution reactions. It is a colorless liquid with a benzene-like odor. In most of its reactions, it resembles benzene. Compounds analogous to thiophene include … See more Thiophene was discovered as a contaminant in benzene. It was observed that isatin (an indole) forms a blue dye if it is mixed with sulfuric acid and crude benzene. The formation of the blue indophenin had long … See more At room temperature, thiophene is a colorless liquid with a mildly pleasant odor reminiscent of benzene, with which thiophene shares some similarities. The high reactivity of … See more • Some Thiophenes • Thieno[3,2-b]thiophene, one of the four thienothiophenes. • 2,2'-Bithiophene. • 3,4-Ethylenedioxythiophene (EDOT) is the precursor to commercial antistatic and electrochromic displays. See more • International Chemical Safety Card 1190 • Chisholm, Hugh, ed. (1911). "Thiophen" . Encyclopædia Britannica. Vol. 26 (11th ed.). Cambridge University Press. See more Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. The first synthesis of thiophene by Meyer, … See more Thiophene is considered to be aromatic, although theoretical calculations suggest that the degree of aromaticity is less than that of benzene. The "electron pairs" on sulfur are significantly delocalized in the pi electron system. As a consequence of its aromaticity, … See more Thiophenes are important heterocyclic compounds that are widely used as building blocks in many agrochemicals and pharmaceuticals. The benzene ring of a biologically active compound may often be replaced by a thiophene without loss of activity. This is seen … See more
Thiophene metabolism
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WebNaturally, thiophenes represent a small family of natural metabolites featured by one to five thiophene rings. Numerous plant species belonging to the family Asteraceae commonly produce thiophenes. These metabolites possessed remarkable bioactivities, including antimicrobial, antiviral, anti-inflammatory, larvicidal, antioxidant, insecticidal, cytotoxic, … WebJan 1, 1991 · Abstract. The objective for this project was to continue the genetic analysis of the thiophene oxidation system, in particular: 1. characterization of the biochemical …
WebSep 29, 2024 · Based on these results, a small but chemically diverse library of guanidine derivatives (15 thiophenes and 2 thiazoles) were synthesised to explore the effect that the bioisosteric change has on affinity and activity at α 2 -adrenoceptors in comparison with our previously studied phenyl derivatives. All compounds were tested for their α 2 ... WebThe four thiophene compounds in Figure 2 have all been identified as causing some toxicity. 25 There is evidence that oxidative metabolism is associated with the toxicity, and there are various proposals 26 for the nature of the toxic intermediate(s), including:
WebThiophene definition, a water-insoluble, colorless liquid, C4H4S, resembling benzene, occurring in crude coal-tar benzene: used chiefly as a solvent and in organic synthesis. … WebFeb 27, 2024 · Nakayama J. et al. have isolated 1,3-dimethyl-2-imidazolidinone upon reaction of 3,4-di-t-butylthiophene S-oxide with 2-methylene-1,3-dimethylimidazolidine (toluene, …
WebFeb 3, 2024 · The compounds such as 3-ethyl-thiophene, 2-propyl-thiophene, 2-butyl-thiophene, and 2, ... > 10 and is produced by trimethylamine oxides through microbial metabolism . Trimethylamine was detected in the edible parts from all three areas, and its concentrations were generally higher in females than in males, especially in the gonads of …
Webthiophene, the simplest sulfur-containing aromatic compound, with molecular formula C4H4S, which closely resembles benzene in its chemical and physical properties. It … intech 20 foot trailerWebJan 1, 2014 · Thiophene 1-oxides are also the key intermediates in the metabolism of the corresponding parent thiophenes in living organisms, rendering them of significant importance in drug metabolism studies . Compared with thiophene 1-oxides, thiophene 1,1-dioxides have been more extensively investigated. intech 20\\u0027 trailerWebJan 14, 2024 · Enzymatic oxidations of thiophenes, including thiophene-containing drugs, are important for biodesulfurization of crude oil and drug metabolism of mono- and poly … intec guaymas