p300 HAT functions as histone acetyltransferase that regulates transcription via chromatin remodeling, and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. p300 HAT contains a … See more Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 See more The p300 protein carries out its function of activating transcription by binding to transcription factors, and the transcription machinery. On the basis of this function, p300 is called a … See more EP300 has been shown to interact with: • BCL3, • BRCA1, • CDX2, • CEBPB, See more • GeneReviews/NCBI/NIH/UW entry on Rubinstein-Taybi Syndrome • GeneCard • EP300+protein,+human at the U.S. National Library of Medicine See more Mutations in the EP300 gene are responsible for a small percentage of cases of Rubinstein-Taybi syndrome. These mutations result in the loss of one copy of the gene in … See more • Condorelli G, Giordano A (1998). "Synergistic role of E1A-binding proteins and tissue-specific transcription factors in differentiation". J. Cell. Biochem. 67 (4): 423–31. doi:10.1002/(SICI)1097-4644(19971215)67:4<423::AID-JCB1>3.0.CO;2-U See more WebJun 25, 2007 · Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer, neurodegenaration, asthma, diabetes, AIDS, and cardiac hypertrophy. We describe the synthesis and characterization of a set of p300-HAT …

Enhancement of the p300 HAT Activity by HIV-1 Tat on …

Webp300, HAT Domain MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. SDS CoA References Key Applications: Histone … WebA colony-formation assay showed that PDT-induced cytotoxicity was dramatically elevated in the presence of the p300HAT inhibitor anacardic acid (AA). Further studies showed that increased p300HAT acetylates histone H3 and NF-κB p65 subunit to up-regulate the COX-2 expression, which was reduced by AA or p300HAT shRNA. scorpion bay restaurant lake pleasant az

Specific Inhibition of p300-HAT Alters Global Gene Expression and ...

Webp300HAT Species H. sapiens (human) Insert Size (bp) 2807 Entrez Gene EP300 ( a.k.a. KAT3B, MKHK2, RSTS2, p300) Promoter T7 Tag / Fusion Protein His6 (N terminal on … WebJul 1, 2024 · The potent catalytic p300HAT inhibitor A-485 induces rapid decay and reduction in breast cancer ERBB2 mRNA expression [abstract]. In: Proceedings of the American Association for Cancer Research... WebGeneral description. A cell-permeable disulfane compound that is reported to be more potent against KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC 50 ≤2, ≤36, ≤60, and >100 µM, respectively) and effectively reduce H3K14, H4K8, H4K16, but not α-tubulin, acetylation level in LNCaP prostate cancer cells (max ... preeti s rawat