WebA tag already exists with the provided branch name. Many Git commands accept both tag and branch names, so creating this branch may cause unexpected behavior. WebNov 17, 2024 · Plasmacytoid dendritic cells (pDCs) are the key producers of type I interferons (IFNs), thus playing a central role in initiating antiviral immune response. Besides robust type I IFN production, pDCs also act as antigen presenting cells post immunogenic stimulation. Transcription factor Irf8 is indispensable for the development of both pDC …
Implications of post-translational modifications of IRF7 …
WebAug 27, 2009 · Type I IFN production by pDCs correlates with differential interferon regulatory factor 7 (IRF7) translocation into the nucleus induced by the 2 TLR7 ligands. Surprisingly, with both activators we nevertheless observed the rapid expression of the IFN-inducible genes mxa, ... Differential pDC maturation is triggered by different TLR7 ligands ... WebSep 13, 2012 · Phosphorylation levels of proteins involved in the TLR7 pathway including IRF7 were measured in pDCs by phospho-flow cytometry at baseline and at different time-points after TLR7 stimulation. The kinetics of IRF7 modifications in the TLR7 pathway were confirmed using mRNA expression of IFN-alpha. grant opportunities for small business
IRF5, IRF8, and IRF7 in human pDCs - Wiley Online Library
WebStrikingly, comparisons between pDC responses of non human primate models with contrasting susceptibilities to SIV-induced disease have demonstrated much higher pDC activation in the susceptible rhesus macaques as compared to the resistant African green monkeys or sooty mangabeys , associated with a polymorphism in the Irf7 gene between … WebJul 4, 2013 · Following phosphorylation, IRF7 translocates to the nucleus and initiates the transcription of type I and type III IFNs. IRF5 positively regulates the induction of pro … WebJun 19, 2024 · To elucidate pDC immunomodulatory functions, we developed a mouse model in which IRF7 signaling is restricted to pDC. Despite undetectable levels of IFN-I … grant opportunities for nonprofits in canada