WebApr 13, 2024 · Mito-TEMPO and MCC950 increased caspase-1p20 and IL-1β expression in THP-1 macrophages, indicating that mitochondrial ROS and autophagy could also interrupt THP-1-M1 macrophage polarization. In conclusion, mitochondrial ROS, ER stress, and the TAMs resulting from OE-KDELC2 glioblastoma cells play important roles in upregulating … Web2 days ago · An Oral Nano-antioxidant for Targeted Treatment of Inflammatory Bowel Disease by Regulating Macrophage Polarization and Inhibiting Ferroptosis of Intestinal Cells. Author links open overlay panel Jing Yang a 1, Yunhao Bai a 1, Shuilin Shen a, ... it can also increase the expression of GSH and GPX4 to protect intestinal cells away from …
Glycogen metabolism regulates macrophage-mediated …
WebThe liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, … WebApr 13, 2024 · Once the quantities of GSH are restricted, excess NAPQI combines with hepatocellular components to generate NAPQI-protein adducts (APAP-protein adducts), which in turn causes mitochondrial dysfunction. ... STING pathway-related inflammation in macrophages leads to the progression of nonalcoholic fatty liver disease (Luo et al. 2024). cottage style bathroom decor
Oxidative stress-induced FABP5 S-glutathionylation protects against ...
WebFeb 6, 2024 · First, we analyzed the effects of GSH-C4 on the inflammatory response induced in LPS-stimulated murine RAW 264.7 macrophages and human primary macrophages. We demonstrated that, GSH-C4 by … WebDec 7, 2024 · Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. WebSep 18, 2024 · The present study investigated the immunomodulatory activity of reduced glutathione (GSH) by assessment of the macrophage polarization (MP)-mediated immune response in RAW 264.7 cells. Furthermore, we identified the signal pathway associated with immune regulation by GSH. breathless cornelia parker