WebWe examined in detail the molecular mechanisms of MUC1.CT signaling that induces the expression of connective tissue growth factor (CTGF/CCN2), a potent mediator of ECM remodeling and angiogenesis. We demonstrate a robust induction of CTGF synthesis and secretion in response to serum factors that is enabled only when MUC1 is highly … WebSelect search scope, currently: articles+ all catalog, articles, website, & more in one search; catalog books, media & more in the Stanford Libraries' collections; articles+ journal articles & other e-resources
Tissue expression of CCN2 - Summary - The Human Protein Atlas
WebOct 26, 2024 · Connective tissue growth factor (CTGF), also known as CCN family protein 2 (CCN2), is composed of four domains, including insulin-like growth factor binding protein-like (IGFBP), von Willebrand factor type C repeat (VWC), thrombospondin type 1 repeat (TSP1), and C-terminal cystine-knot (CT) modules . It is a cysteine-rich … WebConnective Tissue Growth Factor or CTGF is a protein of the extracellular matrix variety. Also known as CCN2, this matricellular protein is part of the CNN group. Connective … open box or refurbished
Connective-tissue growth factor (CTGF) modulates cell ... - Nature
WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the … WebApr 1, 2024 · Based on numerous studies through the decades, the connection between CTGF and the well-known fibrosis-related growth factor transforming growth factor-β (TGF-β) was revealed.The induction of fibrosis by CTGF through different molecular pathways have been reported in the model of hepatic fibrosis, pulmonary fibrosis, renal … WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast … open box record cartridge