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Ctgf growth factor

WebWe examined in detail the molecular mechanisms of MUC1.CT signaling that induces the expression of connective tissue growth factor (CTGF/CCN2), a potent mediator of ECM remodeling and angiogenesis. We demonstrate a robust induction of CTGF synthesis and secretion in response to serum factors that is enabled only when MUC1 is highly … WebSelect search scope, currently: articles+ all catalog, articles, website, & more in one search; catalog books, media & more in the Stanford Libraries' collections; articles+ journal articles & other e-resources

Tissue expression of CCN2 - Summary - The Human Protein Atlas

WebOct 26, 2024 · Connective tissue growth factor (CTGF), also known as CCN family protein 2 (CCN2), is composed of four domains, including insulin-like growth factor binding protein-like (IGFBP), von Willebrand factor type C repeat (VWC), thrombospondin type 1 repeat (TSP1), and C-terminal cystine-knot (CT) modules . It is a cysteine-rich … WebConnective Tissue Growth Factor or CTGF is a protein of the extracellular matrix variety. Also known as CCN2, this matricellular protein is part of the CNN group. Connective … open box or refurbished https://decemchair.com

Connective-tissue growth factor (CTGF) modulates cell ... - Nature

WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the … WebApr 1, 2024 · Based on numerous studies through the decades, the connection between CTGF and the well-known fibrosis-related growth factor transforming growth factor-β (TGF-β) was revealed.The induction of fibrosis by CTGF through different molecular pathways have been reported in the model of hepatic fibrosis, pulmonary fibrosis, renal … WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast … open box record cartridge

Connective-Tissue Growth Factor Contributes to TGF-β1–induced …

Category:Frontiers Connective Tissue Growth Factor: From Molecular ...

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Ctgf growth factor

Connective tissue growth factor: a crucial cytokine-mediating …

WebMar 10, 2024 · Connective tissue growth factor (CTGF), also known as CCN2, is a member of the CCN protein family of secreted proteins with roles in diverse biological processes. … WebOct 4, 2012 · Background The pro-fibrogenic cytokine connective tissue growth factor (CTGF) plays an important role in the development and progression of fibrosis in many organ systems, including liver. However, its role in the pathogenesis of hepatitis C virus (HCV)-induced liver fibrosis remains unclear. Methods In the present study, we assessed …

Ctgf growth factor

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WebConnective tissue growth factor (CTGF) is a secreted protein that binds to integrins, and regulates the invasiveness and metastasis of certain carcinoma cells. Here, we found that CTGF was upregulated in drug-resistant phenotype of human CRC cells. Overexpression of CTGF enhanced the resistance to 5-FU-induced cell apoptosis. WebConnective tissue growth factor (CTGF/CCN2) ELISA: a novel tool for monitoring fibrosis -Dendooven A, Gerritsen KG, Nguyen TQ, Kok RJ, …

WebPamrevlumab, our proprietary fully human antibody, targets connective tissue growth factor (CTGF), the central mediator of tissue remodeling and fibrosis. Pamrevlumab represents a potential treatment for a broad array of fibrotic and proliferative disorders that affect organ systems throughout the body. Pamrevlumab is in Phase 3 clinical studies for … WebAug 6, 2024 · Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis. Main body of the abstract. CTGF can simultaneously interact with several factors with its four domains. The microenvironment …

WebOct 29, 2024 · Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such … WebAug 25, 2009 · Connective tissue growth factor (CTGF) is a secreted protein that is strongly induced in human and experimental heart failure. CTGF is said to be profibrotic; however, the precise function of CTGF is unclear. We generated transgenic mice and rats with cardiomyocyte-specific CTGF overexpression (CTGF-TG). To investigate CTGF as …

WebFeb 25, 2024 · Expression of connective tissue growth factor (CTGF) is elevated in affected organs in virtually every fibrotic disorder and in the diseased human myocardium. Mice were subjected to treatment with a CTGF monoclonal antibody (mAb) during infarct repair, post-MI left ventricular (LV) remodeling, or acute ischemia−reperfusion injury. ...

WebConnective Tissue Growth Factor (CTGF), also known as CCN2, is a 36-38 kDa member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins (1). Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain (2). open box projectorWebAug 1, 1997 · Abstract Connective tissue growth factor (CTGF) is a novel cysteine-rich, secreted peptide, which is implicated in human atherosclerosis and fibrotic disorders … iowa livestock producer relief programWebAug 1, 2024 · CTGF (connective tissue growth factor), also known as CCN2, is one of the best-studied members of the CCN family [1], a family of regulatory proteins of the … open box refrigerator lowesWebConnective Tissue Growth Factor/CCN2. CTGF is a cysteine-rich 40 kDa matricellular growth factor implicated in angiogenesis, wound healing, and development. Although it … open box shelves targetWebOct 29, 2024 · Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, … open box self propelled lawn mowerWebCTGF, connective tissue growth factor; CTX, captopril group; DC, docetaxel-captopril group; DTX, docetaxel group; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; H, control group; STR, stricture ... iowa live streamWebConnective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, … iowa live stream webcam