WebRheumatoid arthritis (RA) is a systemic disease that affects the osteoarticular system, associated with bone fragility and increased risk of fractures. Herein, we aimed to … WebCOLLAGEN-INDUCED ARTHRITIS (CIA) CIA is used by investigators as a mouse model of human RA. Inoculation of certain substrains of DBA/1J mice with type II collagen (CII) …
Background Information Collagen-Induced Arthritis
WebMay 26, 2024 · Although stimulation of collagen-specific T cells is required to induce arthritis, high levels of circulating antibody to CII are strongly associated with the … WebMar 31, 2024 · The altering effect of circRNA_17725 on macrophages in vivo was evaluated using collagen-induced arthritis (CIA) mouse model. circRNA_17725 was demonstrated to be downregulated in peripheral blood mononuclear cells and CD14 + monocytes from RA cases in contrast to healthy controls. The negative association between circRNA_17725 … rtthread getchar
Granulocyte-macrophage colony stimulating factor exacerbates collagen …
WebJul 24, 2024 · CD163 deficiency strongly enhances disease severity in experimental CIA. Mice immunized with chicken type II collagen in adjuvant induced a modest arthritis response in normal C57/BL6 mice as ... WebAug 23, 2010 · Disease severity in collagen-induced arthritis (CIA) is commonly assessed by clinical scoring of paw swelling and histological examination of joints. Although this is an accurate approach, it is also labour-intensive and the application of less invasive and less time-consuming methods is of great interest. However, it is still unclear which of these … WebCollagen-Induced Arthritis (CIA) can be induced in certain strains of mice, rats, and non-human primates by immunization with type II collagen emulsified with adjuvant. To effectively induce CIA in animals, the type of adjuvant used … rtthread go